Hyun Jin did his PhD at Catholic University in South Korea on connections between microRNAs and cancer. While in the Buratowski lab, he was supported by a fellowship from the Korea National Research Foundation. His work involved developing new mass spectrometry methods to analyze patterns of CTD phosphorylation, and how the CTD interacts with the histone H3K4 methyltransferase Set1/COMPASS. He's now working for Korean biopharma company LegoChem Biosciences developing anti-cancer drugs that target transcription.
Former Lab Members
Yoo Jin Joo
Yoo Jin did his PhD work at Korea University where he studied gene expression in yeast. In the Buratowski lab, he created an in vitro system for studying transcription elongation, CTD phosphorylation, and chromatin interactions. He used this system to carry out quantitative proteomic analysis of RNA polymerase II transcription complexes. Yoo Jin is now Chief Research Scientist at TiumBio Co., Ltd., developing drugs for diseases caused by defects in transcription.
Luis is from Lisbon, Portugal. He received his PhD degree from the Faculty of Medicine, University of Lisbon, for his work in splice site recognition done both in Heidelberg, Germany and Barcelona, Spain. In the Buratowski lab he studied the mechanisms of histone H3 K4 methylation. Luis is also an expert on the computational analysis and representation of genomic data. He is currently a Senior Bioinformatician for Foghorn Therapeutics in Cambridge, MA. Luis's LinkedIn profile.
Hyunsuk did his PhD work at Seoul National University. At HMS, he worked on the RNA polymerase II CTD, showing it can be transferred to other polymerase subunits and performing a detailed mass spectrometry analysis of phosphorylation patterns. He is currently a Senior Scientist at Pfizer. Hyunsuk's LinkedIn profile.
Dane got his PhD at Brown University studying lambda phage integrase. In the Buratowski lab he was supported by an American Cancer Society Fellowship and studied the interplay between transcription elongation and termination. After spending several years as a research scientist at the Broad Institute/Stanley Center for Psychiatric Research, he became a Senior Scientist at Vor Biopharma, where he works on engineering human stem cells for cancer therapies. Dane's LinkedIn profile.
Cody is from Michigan and is majoring in Molecular and Cellular Biology at Harvard College. His research studying co-transcriptional histone methylation won two awards: the Henderson Prize for the outstanding thesis in the department of Molecular and Cellular Biology, and the Hoopes Prize, given to the top theses from that year's graduating class. After graduation, Cody is attending medical school at the University of Chicago. Cody's LinkedIn profile.
Hannah did her PhD with Nick Proudfoot at Oxford and did postdoctoral work with Jesper Svejstrup at Clare Hall. She was a visiting scientist in our lab, supported by a Sir Henry Wellcome Trust Fellowship. She's now has her own lab at Kings College London, supported by a Henry Dale Career Development award from the Wellcome Trust.
Susanna is a Professor at the Centro de Investigación Príncipe Felipe in Valencia, Spain. She spent six months in 2015 in the lab on sabbatical, supported by a Fulbright Scholar award. Her lab studies the interactions between transcription and mRNA export. She is an avid runner, and she describes her running experiences in Boston in this article.
Sebastian did his PhD on Arabidopsis gene expression with Caroline Dean at the John Innes Centre in England. In the Buratowski lab he studied the expression of cryptic non-coding RNAs and divergent promoters. He is currently an Associate Professor at the Copenhagen Plant Science Centre. Sebastian has received an ERC Starting Grant (2017) an EMBO Young Investigator Award (2019). Marquardt Lab Webpage.
Current Position: Associate Professor at Ewha Womans University.
Taesoo is from Ulsan, Korea. He earned his PhD from Seoul National Univeristy where he studied yeast transcription. While in the Buratowski lab, TaeSoo studied the relationship between histone methylation and transcription elongation, with a focus on the Set3 histone deacetylase complex. He was supported by a Special Fellowship from the Leukemia and Lymphoma Society and a SPORE grant from the National Cancer Institute.
Tim is from New Jersey and received his undergraduate degree in Biochemistry from the University of Pennsylvania. Tim was co-advised by Jarrod Marto at Dana Farber Cancer Institute studied transcription initiation complexes using quantitative mass spectrometry. After graduating he joined the postdoctoral fellows program at Glaxo Smith Kline in Pennsylvania, where he is now an Investigator. Tim's LinkedIn profile.
Nihal earned her B.S. in molecular biology and genetics from Bilkent University, Turkey, in 2005. In the Buratowski Lab, she studied the interactions between histone modifications and transcription termination. After graduating in 2011 she joined Stuart Orkin's lab as a postdoctoral fellow. In 2016 she moved back home and is now an assistant professor at Middle East Technical University.
Miriam did her PhD at Rutgers University in New Jersey. Her postdoctoral work addressed the role of the mRNA binding protein Npl3 in mRNA termination and export. She spent time on the faculty at UMass Medical School in Worcester and is currently an editor at the Journal of Molecular Biology. Miriam's LinkedIn profile.
Minkyu Kim earned his PhD from Seoul National University where he studied DNA damage response in fission yeast. His research in the Buratowski lab focused on how eukaryotic RNA polymerase II terminates transcription. After leaving the Buratowski lab, Minkyu was an Assistant Professor at Seoul National University until 2015, when he joined the California Institute for Quantitative Biosciences at UCSF. Minkyu's UCSF profile
Currently a faculty member in the Dept. of Biochemistry, Oxford University, Lidia is from Krasnoyarsk, a very beautiful city in the middle of Siberia, Russia. She earned a Masters of Science from the Institute of Protein Research, RAN, in Pushchino, Russia. She went on to earn a PhD from the University of Helsinki, where she studied the replication of positive strand RNA viruses. Her work in the Buratowski lab connected RNA synthesis and termination to quality control by the exosome.
Jessica obtained her B.A. in Biology-Chemistry from Scripps College in Claremont, CA in 2001. Her work focused on studying the regulation of RNA polymerase II elongation, more specifically the role of the Paf1 complex as well as the SR protein, Npl3. After graduation, Jessica did postdoctoral work at Stanford and is currently Director of R&D Science at the company ProteinSimple. Jessica's LinkedIn profile.
Vanessa is from California. After graduating with a B.S. in Biology from Pepperdine University in 2001, In the Burtatowski lab, she studied the roles of the Rpb4 subunit of RNA polymerase II during the process of transcription. She is currently a postdoctoral fellow at Brigham and Women's hospital.
Michael started out working on CTD kinases, but this led to his pioneering work on histone modifying enzymes. In 2006 Michael started his own lab at Albert Einstein College of Medicine, and more recently he became the Chief Scientific Officer of the epigenetics company EpiCypher. Michael's LinkedIn profile.
Marie-France did her PhD at the Institut de recherches cliniques de Montreal on RNA polymerase II and was awarded a CIHR Postdoctoral Fellowship. She stayed at Harvard only one year, but during that short time met John Pascal, who is now her husband. They moved to Thomas Jefferson University in Philadelphia, where together they've been doing outstanding work on DNA repair enzymes. More recently, they've moved to the University of Montreal.
Seong-Hoon studied at Sungkyunkwon University before coming to the Buratowski Lab for postdoctoral work. He was a key part of our team that discovered how the RNA polymerase II CTD is used to couple transcription with mRNA processing and chromatin modifying enzymes. He is now a full Professor at Hanyang University back home in Korea.
Oranart (Noon) Matangkasombut
Noon is from Thailand, and grew up in an academic family. Her undergraduate major is dentistry, and she came to Harvard Dental School for her PhD. Her thesis work was on Bdf1, a yeast bromodomain protein involved in gene expression. After graduation, she did postdoctoral work at MIT and then joined the faculty at Chulalongkorn University back home in Thailand.
Eun-Jung received her PhD from Seoul National University. She was a member of the Buratowski lab from 1996-2001, where she was the first person to show that the phosphorylated RNA polymerase II C-terminal domain is necessary for recruiting mRNA processing enzymes such as the capping enzyme. She is currently a Professor at Sunkyunkwan University.
Philip is originally from Ukraine, got his undergraduate and masters degrees in medicine from Moscow State University, and his PhD at University of New Hampshire. As a postdoc, he did groundbreaking work on TFIID TAFs, and together with Eun-Jung Cho, showed that changing RNA pol II CTD phosphorylation patterns during elongation recruited different RNA processing factors. After leaving the lab, Philip went to the MIT Sloan School for his MBA, and since then has been working in Boston's biotech sector. Philip's LinkedIn profile.
Toshi Takagi obtained his MD from Kyushu University and his Phd at University of Tokyo. He did postdoctoral work in the Buratowski lab from 1996 to 2000 with support from the American Cancer Society. In the process of identifying the first higher eukaryotic capping enzyme gene, he discovered a new class of RNA phosphatases that resembled protein tyrosine phosphatases. Since leaving the lab, he has been a senior research scientist at Shionogi BioResearch, Merck, and Rosetta. After many years running the high throughput drug screening at the Sloan-Kettering Institute, Toshi recently moved to Poland to become the Director of High-Throughput Screening at Captor Therapeutics. Toshi's LinkedIn Profile.
Christine (Moore) Rodriguez
Christine's dissertation work was on mRNA capping enzyme and its interactions with RNA polymerase II. After graduation, she pursued her long-time ambition in science education and currently teaches at both Fairfield University and Sacred Heart University. Christine's LinkedIn profile.
Bertha was a postdoctoral fellow in the Buratowski lab from 1996-1999, supported by a fellowship from Mexico's CONACYT. While here, she worked on the TFIID TAF subunits. She currently is on the faculty at the Universidad Nactional Autonoma de Mexico.
Natalie did her PhD at Harvard studying bacterial transcription. Supported by an NIH Postdoctoral Fellowship, her postdoc research studied the basal transcription factor TFIIE. She then pursued her passion for teaching science as an Instructor at Wellesley University and then MIT. As the founder and president of BioBuilder Educational Foundation, she now brings her expertise to help teachers everywhere bring synthetic biology to their students. Natalie's LinkedIn page.
Jessica worked in the lab a research technician in between her Master's Degree at Boston University and her PhD at Cambridge University. She's been in the UK ever since, and is currently a Professor at the Institute for Cancer Research in London, studying the role of chromatin epigenetics in cancer.
Lucille (Lulu) Fresco
After getting her PhD from Duke University, Lulu Fresco spent a short postdoc period with Don Rio at MIT. When the Rio lab moved to UC Berkeley, Lulu came to the Buratowski lab where she mapped the active site of capping enzyme and showed that capping is important for efficient mRNA splicing. She currently resides in Princeton, NJ with her beautiful family.